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Only tamoxifen has enough evidence to recommend it for the prevention of breast cancer, and its use is limited to very high-risk women with a low risk of side effects.
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The value of neoadjuvant chemotherapy for invasive bladder cancer had not been definitively established, possibly because clinical trials have been of insufficient size to demonstrate efficacy.
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In a multicenter trial from Japan, Bestatin, an aminopeptidase inhibitor, was shown to enhance survival in patients with stage I sqaumous cell carcinoma of the lung.
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There have been no randomized trials comparing surgery and radiotherapy for solitary brain metastases, nor are there well-defined guidelines for the management of these patients.
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An increased risk of cervical cancer is associated with long durations of use of hormonal contraceptives.
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New clinical practice guidelines for the prevention, detection, and treatment of high blood pressure recommend earlier and more aggressive intervention for control of the disease.
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The U.S. Food and Drug Administration (FDA) and the National Cancer Institute (NCI) have recently announced that they will share knowledge and resources to facilitate the development of new cancer drugs and speed their delivery to patients.
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In the Pipeline
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The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) provides new clinical guidelines for hypertension prevention and management.
